Objective Measuring the success of molecularly guided therapies is a major challenge in precision oncology trials.A commonly used endpoint is an intra-patient progression-free survival (PFS) ratio, defined as the PFS interval associated with molecularly guided therapy (PFS2) divided by the PFS interval associated with the last prior systemic therap
ABSTRACT Mammals maintain close associations with gut microbes that provide numerous nutritional benefits, including vitamin synthesis.While most mammals obtain sufficient vitamins from their diets, deficiencies in various B vitamins (biotin, cobalamin, riboflavin, thiamine, etc.) are reported in captive animals.Biomedical and agricultural research
The gloomspite gitz art susceptibility of crop plants towards abiotic stresses is highly threatening to assure global food security as it results in almost 50% annual yield loss.To address this issue, several strategies like plant breeding and genetic engineering have been used by researchers from time to time.However, these approaches are not suff
Two methods were developed for the generation of cisgenic apples.Both have been successfully applied producing trees.The first method avoids the use of any foreign selectable marker genes; only the gene-of-interest is integrated between the T-DNA border sequences.The second method makes use of recombinase-based marker excision.For the first method
A brain-machine interface (BMI) is a neuroprosthetic device that can restore motor function of individuals with paralysis.Although the feasibility of BMI control of upper-limb monster scooter batteries neuroprostheses has been demonstrated, a BMI for the restoration of lower-limb motor functions has not yet been developed.The objective of this stud